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advice on first server

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advice on first server

Received a second-hand ProLiant ML370, and I've been asked to set it up. I have NO experience with servers.
40 users, functions: primarily file server, with database apps later. Light to medium use.
My first concern is how many/what size drives to buy. I've seen some posts on mirroring the OS Raid 1, and putting the data on Raid 5. Would this work with database apps as well? Would programs go on data or OS raid?
Or would it be fine to use one array? If so, should I fill the bays with small drives, or buy a few large drives, so I can add more later without having to scrap all existing drives? Thanks