4000m Since going to 9.16

[Nicholas_18]

We have upgraded to 9.16 and since then we have very high rate of packet collisions, drop and packet errors, have tried all settings and the only one that works is to set the desktop to 10hdx and leave the switch at default. We have tried setting the nic and port to definate values and it makes no difference ! very bad performance when switch port is set to 100fdx and nic is set to 100fdx. as with 100hdx and 10fdx. I dont think that this is a cabling issue as nothing has changed.
Does Flow control need to be on ?
We have three 4000m's trunked together with J4121a modules.
Tried going back in versions but that made no difference either