Hi Chris,
I've written a technical paper that deals with this exact scenario. There may be ways for you to get your client back in order without rebooting it, even without a forcible unmount facility.
The technical paper is titled "Forcibly Unmounting NFS Filesystems" and it is located at:
http://docs.hp.com/hpux/onlinedocs/3929/ForciblyUnmountingNFSFilesystems.pdf
Hopefully some of the tricks in this guide will help you resolve your problem.
In case you haven't heard, HP will be providing the ability to forcibly unmount hung NFS filesystems in the very near future. In October (current plan) we will release HP-UX 11i v2 update 2, which will allow HP-UX 11i v2 to run on both PA-RISC and Itanium processors. One of the new features that we've added to this release is forcible NFS unmounts. Once 11i v2 update 2 is installed, you could do a "unmount -f " and the client will forcibly unmount the filesystem, even if there are pending I/Os on the device.
For now, your best bet is to try the tricks I outline in the technical paper.
Good luck,
Dave