Hi Enrico,
I'm sorry to say, but this is definitely not good.
1) Cross-device link usually indicates that this PV has been included in another VG - possibly on another system even. If this is a shared array, verify this PV is NOT in another VG. If it is & it shouldn't be - remove it from that unnecessary VG
2)Activation mode generally means you need to make the VG cluster-aware:
vgchange -c y /dev/vg_161
3) Couldn't query means this system does not think c4t8d0 belongs to vg_161. Check the /etc/lvmtab to see what it thinks vg_161 should contain & if it is incorrect, mv or delete it & and run vgscan -v to recreate a new one w/the correct info.
4) Couldn't query all says that again lvmtab states that vg_161 contains more/different PVs than what the system actually sees. Again this could point to lvmtab being bad or corrupt. I'd say definitely rebuild lvmtab.
HTH,
Jeff
PERSEVERANCE -- Remember, whatever does not kill you only makes you stronger!