Sure sounds like there is a problem.
Is the OS software up to date?
Which exact version + patch kits?
And uh... being curious, what are all those luns doing? Petabytes of storage, or perhaps lots of 'little' luns ( < 50GB ) ?
If so, why not fewer large ones?
If need be, carve them up in software with LSM?
Regards,
Hein van den Heuvel
HvdH Performance Consulting