The new HPE ProLiant Compute Gen12, powered by 5th Gen AMD EPYC processors

[ComputeExperts]

HPE introduces two new HPE ProLiant Compute Gen12 servers, powered by 5th Gen AMD EPYC processors: HPE ProLiant Compute DL325 Gen12 and the HPE ProLiant Compute DL345 Gen12

Answering the call for compute innovation

Delivering the next-level security features, performance, and efficiency that organizations need to drive innovation and support transformation company wide, HPE ProLiant Compute Gen12 with 5th Gen AMD EPYC processors is the answer to today’s top business challenges.

With HPE ProLiant Gen12 systems powered by AMD technology, organizations can:

• Count on the HPE iLO multilayer silicon root of trust to protect servers from manufacturing through end-of-life while providing compliance readiness for future quantum-computing attacks. Trust AMD Infinity Guard,¹ built-in at the silicon level, offering advanced capabilities to help defend against internal and external threats and keep your data safe.
• Get up to 41% higher performance per watt (compared to HPE Gen10 systems)¹ to run new AI and edge workloads, as well as boost VDI efficiency—all while saving space and consuming less energy.
• Enable operators to react quickly and gain greater control—from forecasting energy costs to managing a global server footprint—with new AI-driven insights.

Introducing HPE ProLiant Compute DL325 Gen12

Delivering exceptional value, the 1U/1P HPE ProLiant Compute DL325 Gen12 with 5th Gen AMD EPYC processors supports up to 192 cores and 500 watts to deliver proven performance, efficiency, and density. This platform is an excellent choice for running a variety of essential business applications, including:

• Enterprise risk management, helping your security team identify and manage risks that could impact your organization
• Customer relationship management, enabling you to improve customer interactions to enhance loyalty and sustain long-term relationships
• Digital services, including digital marketing, e-commerce, online education, online banking, and streaming media

Affordable yet powerful, this server is delivered in a short-depth form factor, making it a smart choice for any location, including edge and near-edge sites.

  Figure 1. The HPE ProLiant Compute DL325 Gen12 with 5th Gen AMD EPYC processors

Introducing HPE ProLiant Compute DL345 Gen12

With up to 6 TB DDR5 and 2 DIMMS per channel delivered in a scalable 2U chassis, HPE ProLiant Compute DL345 Gen12 with 5th Gen AMD EPYC processors is the perfect choice for powering a wide range of data-intensive workloads, including:

• For VDI workloads, desktop environments are hosted on a central server. Common use cases include secure access for remote workers and managing diverse user needs across call centers, healthcare organizations, and other highly regulated organizations.
• For hybrid cloud workloads, your on-premises private cloud runs in concert with the public cloud to support a wide range of use cases, including digital transformation, disaster recovery, dev/test activities, edge computing, and (of course) AI.
• End-to-end database management keeps your data organized and accessible to users through efficient storage and retrieval, supporting digital transformation, data migration, AI, analytics, and more.
• Endpoint management helps ensure all devices connected to your network are secure and compliant with your organizational policies while also simplifying device onboarding, managing remote work, and deploying and updating applications.
• Lifecycle management optimizes and prioritizes your organizational data, from acquisition to disposal.

  Figure 2. HPE ProLiant Compute DL345 Gen12 with 5th Gen AMD EPYC processors

This flexible server is ready to grow with your business as your applications and workloads evolve.

Latest technology advancements

Regardless of which AMD CPU-powered HPE ProLiant Gen12 model you choose, you will benefit from a server architected with exclusive technology advancements for security, optimization, and automation. The latest Gen12 systems include:

• New data center modular hardware system creates a flexible, scalable approach to managing the physical IT infrastructure.
• New HPE iLO 7 provides next-level security, helping to protect sensitive data.
• New front-capable I/O, with up to 4 PCIe Gen5 slots and 2 OCP, is for easy accessibility in space-constrained data centers.
• New direct liquid cooling support is included for both HPE ProLiant Compute DL325 Gen 12 and HPE ProLiant Compute DL345 Gen12 platforms.

 Visit us at HPE Discover Las Vegas, June 23–26, 2025, and stop by the AMD Booth #3000

Engineered for the hybrid world, HPE ProLiant Compute DL325 Gen12 and HPE ProLiant Compute DL345 Gen12 with 5th Gen AMD EPYC processors are the latest additions to the Gen12 portfolio. With these new compute platforms, you can power next-generation workloads with the efficiency you demand while addressing inefficiencies, streamlining operations, and boosting security.

HPE ProLiant Compute Gen12 platforms powered by AMD CPUs are:

• Secured with a robust, security-first design
• Optimized for more performance and efficiency
• Automated and AI-driven to boost productivity

References

Solution brief

Decision tree 

HPE ProLiant Compute DL325 product tour

HPE ProLiant Compute DL345 product tour

Learn more at

HPE.com/us/en/solutions/amd.html

https://www.hpe.com/psnow/doc/a00149593enw 

[1] GD-183A: AMD Infinity Guard features vary by EPYC Processor generations and/or series. Infinity Guard security features must be enabled by server OEMs and/or cloud service providers to operate. Check with your OEM or provider to confirm support of these features. Learn more about Infinity Guard.

Meet the Author:

Kristen Fohl, AMD Compute Product Marketing Manager